MH 113 Fundic Stomach

Fundic Stomach

This specimen contains furrows in the mucosa that divides the surface of the stomach into bulging irregular areas called .

: Surface invaginations lined with surface mucous cells
: Long glands that contain three main cell types:
- : Scattered narrow, basophilic cells found in the isthmus and neck between parietal cells
  - Basophilic due to abundant rough endoplasmic reticulum
  - Mucus in secretory cells appear pale or slightly basophilic
- : Strongly eosinophilic cells with a large, oval shape and a central nucleus found throughout the gland
  - Bright pink-red staining results from their extraordinarily abundant mitochondria
  - Energy-demanding process of acid secretion via H⁺/K⁺ ATPase pumps
- : Smaller, basophilic cells found in the lower portions of the glands
  - Basophilic, particularly in their basal cytoplasm, due to abundant rough endoplasmic reticulum
  - Synthesize pepsinogen and other digestive enzymes

The contents of the stomach, called chyme, is mixed and propelled by slow waves of rhythmic contractions called peristalsis.

: Ganglion cells and fibers in the submucosa that regulate smooth muscle cells in the submucosa and muscularis mucosae.
: Ganglion cells and fibers between layers of the muscularis externa that regulate their contraction.